CD274 and neoplasm: Some mutations in exon 13, which hosts the exonuclease domain, can generate more than 8,000 neo-epitopes, favoring and determining a highly immunogenic microenvironment, as highlighted by an increase in the number of peri-tumor and tumor-infiltrating lymphocytes (TILs) and by a concomitant high expression of PD-1 or PD-L1 (25).