AKT1 and hepatocellular carcinoma: Furthermore, FTCD has been shown to positively influence the suppression of HCC through the regulation of apoptosis, DNA damage repair, and the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway (34).With regard to prognosis, a decrease in FTCD expression has been positively correlated with favorable outcomes in HCC (35, 36).