In our study, comparing HIV‐infected patients (absolute CD4+ T cell count > 200 cells/μL) with patients with mycobacterial infection, it was obvious that compared with HIV‐infected patients, patients with HIV and mycobacterial infection not only had a lower number of T cells but also had lower mitochondrial quality and a higher percentage of cells with lower MMP compared to patients with HIV infection; maybe they were in an immunosuppressed state. This evidence concerns the gene CD4 and HIV infectious disease.