Gigaxonin has been previously reported to be crucial for the turnover of neural intermediate filaments and the cytoskeleton.[26, 27, 28] Mutations within the gigaxonin gene cause a severe inherited neurodegenerative disorder, giant axonal neuropathy.[29, 30, 31] Although gigaxonin is widely distributed, its function beyond the nervous system remains unclear. The gene discussed is GAN; the disease is giant axonal neuropathy.