TREX1 and familial chilblain lupus: [19, 20] Furthermore, multiple mutations within the TREX1 gene result in cGAS‐driven immune activation and cause multiple type I IFN‐associated autoimmune diseases, such as AGS), familial chilblain lupus, and retinal vasculopathy with cerebral leukodystrophy.[21, 22, 23] Therapeutic modalities that target TREX1, such as small‐molecule inhibitors, have been reported to be efficient for the treatment of tumors associated with cGAS.[24, 25] Although the importance of TREX1 for health has been reported, how TREX1 is precisely regulated to maintain immune homeostasis is still largely unknown.