COA4 and neoplasm: Prior studies have demonstrated that KRAS‐driven lung tumors exhibit increased glucose flux into the tricarboxylic acid (TCA) cycle, with mitochondrial pyruvate metabolism being essential for tumor formation in vivo.[35] In our study, we show that KRAS drives COA4 expression via the PI3K pathway, and that COA4 is markedly overexpressed in LUAD tissues with KRAS mutations or high KRAS expression.