As COA4's pro‐metastatic role in PAAD remains unreported, we selected the KRASG12D‐mutant ASPC‐1 cell line from DepMap/MetMap databases—characterized by high COA4 expression and metastatic competence—and established stable COA4‐knockdown (shCOA4‐luciferase) cells (Figure S8H, Supporting Information). Here, COA4 is linked to pancreatic adenocarcinoma.