Overall, while there are several limitations to our study which deserve further exploration and clinical validation, we nevertheless provide strong evidence that CDK4/6i priming before anti‐PD‐1 therapy is a promising sequential modality in HNSCC and IL15‐secreted Sell(hi) neutrophils induce Stat5+ progenitor CD8+ T cells is functionally involved in the generation of response. This evidence concerns the gene IL15 and head and neck squamous cell carcinoma.