CD8A and neoplasm: Previous studies have shown that Stat5a opposes the transcription factor Tox, redirecting exhausted CD8+ T cells toward durable effector‐like/exhaustion‐resistant states, enhancing polyfunctionality and antitumor immunity.[27] Neutrophils are generally pro‐tumorigenic; however, recent research revealed that both anti‐ and pro‐tumor neutrophils coexist within tumors without differentiating.[42, 43] Here, we identified an Sell(hi) neutrophil cluster that increased predominantly in CDK4/6i monotherapy or priming groups.