HSPA5 and neoplasm: These GRP78s will be delivered to the Golgi apparatus with COPII vesicles and then be released in the form of secretory vesicles.[32, 33] Second, sGRP78 can also be secreted along with tumor‐released exosomes.[34] Third, we suggest that tumor cell membranes would be the major source of sGRP78 because chemotherapeutics treatment could quickly reduce the GRP78 level on the cell membrane while elevating its serum level.