The top 20 significant KEGG pathways are involved in disease or immune functions including NF-κB signaling pathway, Osteoclast differentiation, TNF signaling pathway, COVID-19, and Chemokine signaling pathway, among others (Fig. 3C) while the top 20 significant GO-BP terms also involved in immune responses included regulation of defense response, response to cytokine, and regulation of immune response, etc. (Fig. 3D). Here, TNF is linked to COVID-19.