In line with the GO-BP terms, the KEGG pathways for the S. chromogenes-positive group involved in immune signaling and inflammatory responses, included Osteoclast differentiation, NF-κB signaling pathway, Viral protein interaction with cytokine and cytokine receptors, TNF signaling pathway, JAK-STAT signaling pathway, and Pathways in cancer etc. (Supplemental Table S6J). This evidence concerns the gene IL18R1 and cancer.