Serum kisspeptin levels were 85.18 ± 20.47 ng/dL in group A, 109.37 ± 28.64 ng/dL in group B, and 108.70 ± 32.30 ng/dL in group C. It represented significantly lower serum kisspeptin levels in fertile men (group A) as compared to infertile men (groups B and C) regardless of semen parameters. The gene discussed is KISS1; the disease is Infertility.