On the other hand, patients who were female, nonsmokers, had an ECOG score of 0, had pathological type of ADC, had KRAS mutation on KRAS mutation in other exons besides exon 2, had received 1st-line of standard treatment, or had fewer than 3 metastases, received more benefit in terms of PFS (Supplementary Table 5). The gene discussed is KRAS; the disease is AIDS dementia complex.