KRAS and non-small cell lung carcinoma: KRAS-mutant NSCLC has been considered undruggable in recent decades9 because of the various KRAS mutants, including G12C, G12D, G12S, G12V, Q61H, etc.,6,7,14 as well as structural challenges associated with the KRAS protein.20 However, recent advances have shattered this conventional wisdom.