Our scRNAseq dataset suggested widespread expression of IFNγ receptor (IFNγR)-encoding genes (Ifngr), including in TECs (Fig. 6g)—a pathway that has previously been implicated in mediating TEC cell death in acute graft-versus-host disease (GVHD) after HCT18,40. Here, IFNGR1 is linked to acute graft versus host disease.