MAPT and Alzheimer disease: Studies clarifying the separate pathologic courses of tau and amyloid deposition in AD indicate that the progression of tau pathologies demonstrates a typical regional propagation pattern, in contrast to the diffuse deposition of amyloid (5,31,32); that global amyloid deposition precedes widespread tau dispersion (2,3); that the interaction between 2 pathologies leads to rapid and devastating disease progression (2,30); and that tau deposition near the medial temporal cortex relates to earlier cognitive dysfunctions such as episodic memory loss (3,31) as demonstrated in this study.