Although the exact etiology of PMS remains unclear, various contributing factors have been proposed, including increased secretion of, or sensitivity to, prolactin, fluctuations in hormones (e.g., estrogen and progesterone), imbalances in neurotransmitters (e.g., serotonin and gamma-aminobutyric acid), dietary deficiencies, and genetic predisposition [6]. This evidence concerns the gene PRL and premenstrual tension.