APC and hyperinsulinemic hypoglycemia, familial, 4: Similarly, the identification of the purplecluster associated with Apc deficiency driven by a secondary bileacid such as (tentatively assigned) taurocholic acid may give valuableinsight into the comparative biology of transformed versus normalintestinal enterocytes and relate to the critical role played by thegut microbiome in initiation and progression of colorectal cancer.