To decipher the effect of increased glucosylceramides on tumor progression, we overexpressed UGCG transcript-encoding cDNA in MCF-7 (MCF-7_UGCGOE) and BT-474 (BT-474_UGCGOE) cells representing the luminal breast cancer subtype (Figs 1I and S1C). The gene discussed is UGCG; the disease is breast carcinoma.