APOB and Sepsis: When the combined effects of ApoB, LDL-C, TG, TC, and Lp(a) were examined in Model 1 using the multivariable IVW method, in contrast to univariable MR, heightened levels of total cholesterol exhibited an association with lower risk of sepsis in multivariable MR (OR 0.779, 95% CI 0.642–0.944; P = 0.01) (Fig 3A).