Instrumental heterogeneity was observed at the statistical threshold of 0.05 when analyzing the causal effect of HDL-C on sepsis, ApoA-I on sepsis (sepsis under 75), and TC on sepsis (sepsis with critical care) (Cochran’s Q test, p < 0.05; Supplement Table 2 in S2 File); Consequently, we used the random-effects IVW method. The gene discussed is APOA1; the disease is Sepsis.