SNPs that reduce the activity of ANGPTL3 had an obvious protective effect on sepsis in both the IVW method (OR 0.676, 95% CI 0.525–0.870; P = 0.002) and weighted median method (OR 0.664, 95% CI 0.501–0.881; P = 0.004). Here, ANGPTL3 is linked to Sepsis.