Additionally, SNPs that reduce the activity of HMGCR and LDLR were associated with an increased risk of sepsis (OR 1.300, 95% CI 1.235–1.369; P = 1.38E-23), (OR 1.136, 95% CI 1.010–1.276; P = 0.032), while the inhibition of PCSK9 did not have a causal effect on sepsis risk (IVW method: p = 0.859). The gene discussed is PCSK9; the disease is Sepsis.