We obtained the GWAS summary statistics for clinically diagnosed AD, three AD pathologies (gpath, amyloid, tangles), and three non-AD pathologies including TDP-43 (tdp_st4_binary)[63–67], hippocampal sclerosis (hspath_typ) [67–69], and cortical Lewy body (dlbany) [70–72], from the ROSMAP study. The gene discussed is TARDBP; the disease is Alzheimer disease.