Moreover, Hong et al. [82], using single-cell RNA sequencing of endothelial cells from a murine model of LPS-induced acute lung injury (PpardEC-KO mice), reported that elevated STAT1-dependent CXCL-10 production was associated with increased endothelial permeability, promoting pulmonary vascular leakage. The gene discussed is CXCL10; the disease is acute lung injury.