Therefore, although IFN-STAT1-dependent pro-inflammatory and antiviral factors could play a key role in promoting more complex and effective immune response to control DENV infection, an exacerbated or uncontrolled production of IFNs and STAT1-dependent inflammatory factors may promote excessive inflammation and immunopathology, as has been observed in other viral infections, including those induced by chikungunya virus (CHIKV), and Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 [44,63]. The gene discussed is STAT1; the disease is viral infectious disease.