Additionally, DENV-2 infection also upregulated mRNA expression of macrophage enzymes involved in the induction of inflammatory response, including Cyclooxygenase 2 (COX2), which was induced during the early hours of infection (1.5 to 3 h.p.i), followed by a decrease in expression levels between 5 and 10 h.p.i, and a subsequent peak at 24 h.p.i (Figs 3E, S2D). Here, PTGS2 is linked to infection.