During SARS-CoV-2 infection, monocytes and macrophages detect viral particles and produce IL-6, IL-1β, and IFN-π/IL-27 through TLR, NF-κB activation, and inflammasome assembly, contributing to acute respiratory distress syndrome (ARDS) and severe COVID-19 [63,87,88]. Here, NFKB1 is linked to acute respiratory distress syndrome.