Moreover, high serum levels of TNF-α, IL-1β, IL-6, CXCL-8/IL-8, and IL-10 correlated with severity of the disease in dengue patients [8,9,11,67], showing a preponderant role of NF-kB-dependent inflammatory response in dengue immunopathogenesis. The gene discussed is CXCL8; the disease is dengue disease.