In this study, we collected longitudinal blood samples from patients from Nairobi (urban) and Kilifi (rural) with varying degrees of COVID-19 severity (asymptomatic, mild/moderate and severe) and compared levels of their ex vivo SARS-CoV-2 Spike peptide-specific IFN-γ producing cells, and levels of plasma cytokines and chemokines over their first month of COVID-19 diagnosis. Here, IFNG is linked to COVID-19.