Owing to the challenges associated with obtaining a model for specific cDC1 depletion in vivo, previous studies investigating the role of cDC1 cells in atherosclerosis using various knockout mice have produced conflicting results (Legein et al., 2015; Gil-Pulido et al., 2017; Choi et al., 2011; Clément et al., 2018; Haddad et al., 2017). This evidence concerns the gene MPPE1 and atherosclerosis.