Here, we established a novel Cre line Xcr1Cre-Gfp mice and did not observe any leakiness of Cre activity, and further experiments revealed that specific depletion of cDC1 attenuates atherosclerosis development by inhibiting both CD4+ and CD8+ T cell activation in hyperlipidemic Xcr1Cre-Gfp Rosa26LSL-DTA Apoe–/– mice. This evidence concerns the gene CD4 and atherosclerosis.