Xcr1+ type 1 conventional dendritic cells (Xcr1+ cDC1) (also known as CD8+ DC or CD103+ DCs) has been recognized for their role in cross-presentation and activating naive CD8+ T cells, and are critical for anti-viral and anti-tumor immune responses (Eisenbarth, 2019; Bayerl et al., 2023). The gene discussed is MPPE1; the disease is neoplasm.