In contrast, Irf8 or Dngr1 deficiency reduced the development of atherosclerosis, while Flt3 deficiency exacerbated the condition (Legein et al., 2015; Gil-Pulido et al., 2017; Choi et al., 2011; Clément et al., 2018; Haddad et al., 2017). The gene discussed is CLEC9A; the disease is atherosclerosis.