KLK3 and pachyonychia congenita: Recent advancements incancer biomarker analysis and proteomicresearch are crucial for understanding cancer biology. Prostate cancer (PC) is the most frequently diagnosed cancerin men globally and can be life-threatening. Prostate-specific antigen (PSA) is a glycoprotein with a molecularweight of 30 kDa, is secreted throughthe prostate gland, and is a well-known biomarker of PC when presentin significant quantities in the blood.