Ataxia was similarly significantly increased in the forelimbs (0.3 (0.5) vs 0.2 (0.4) p = 0.002) and all limbs (0.5 (1.0) vs. 0.4 (0.2) p = 0.008) of aged M83+/− mice as compared to age-matched C57BL/6J control (Figure 8A). This evidence concerns the gene PGAP6 and Ataxia.