We assessed the diagnostic performance of four fC1INH assays in a cohort of 148 HAE patients: 84 with HAE-C1INH (72 type 1 and 12 type 2) and 64 with HAE-nC1INH (53 HAE-FXII and 11 HAE-UNK). This evidence concerns the gene UNK and hereditary angioedema.