The percentage of CD4+ lymphocytes expressing CHOP, and CHOP MFI on CD4+ cells were significantly higher in elderly sepsis patients than non-elderly ones (95.5% versus 81.1%, P=0.004; and 334.4 versus 164.2, P<0.0001, respectively), and at the same time the MFIs of mTOR, P62, and LC3II on CD4+ T lymphocyte were also significantly higher. The gene discussed is DDIT3; the disease is Sepsis.