Additionally, in gingival samples, the mRNA expression of pro-inflammatory cytokines (Il1β, Il17a, Il6 and Tnfα) was lower in the cKO-LPS group than in the WT-LPS group, whereas that of IL-10 was higher (Supplementary Figure S2A), indicating that both periodontal destruction and gingivitis were mitigated in the absence of Stat3 in Th17 cells. Here, IL6 is linked to gingivitis.