For example, a study showed that the combination of a chemotherapy agent, cyclophosphamide, with macrophage inhibition using either PLX3397 (a CSF1R inhibitor) or an anti-CSF1R antibody, led to increased infiltration of T and B cells into the tumor microenvironment and resulted in durable tumor regression in TNBC models (85). This evidence concerns the gene CSF1R and neoplasm.