CTLA4 and psoriasis: In recent studies, the potential of adoptive Treg cell therapy in psoriasis treatment was explored by developing a novel platform for local delivery of cell product and showed substantial amelioration of psoriasis in a mouse model (150), and further therapeutic potential was demonstrated using a CTLA-4 signaling peptide (dNP2-ctCTLA-4) in psoriasis by augmenting Treg/Teff ratio (151).