EZH2 and rheumatoid arthritis: PRC2, polycomb repressive complex 2, particularly its catalytic subunit EZH2, is necessary for establishing an epigenetic landscape that supports effector Treg survival; EZH2 deficiency disrupts this balance and contributes to autoimmune pathology in both rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) models (25, 26).