Both in vivo and in vitro cell culture studies have demonstrated that zinc deficiency is correlated with increased levels of oxidative stress markers, such as thiobarbituric acid-reactive substances (TBARS) and protein carbonyls (PCs), as well as increased levels of inflammatory cytokines, including IL-1β, IL-6, and TNF-α (Doboszewska et al., 2016[121]). The gene discussed is IL6; the disease is Zinc deficiency.