Suppressing Mn-SOD expression or inhibiting AMPK results in the inhibition of this metabolic shift and decreases the survival of transformed cells, highlighting the importance of the Mn-SOD/AMPK pathway in maintaining the bioenergetics of cancer cells, particularly in advanced and aggressive subtypes of breast cancer (Baj et al., 2023[23]; Hart et al., 2015[185]). This evidence concerns the gene SOD2 and cancer.