PRDM16 and acute myeloid leukemia: The PRDM16 gene codes for a zing-finger protein containing a DNA-binding PRDI-BF1/RIZ homologous (PR) domain, and it is commonly rearranged in hematologic malignancies of myeloid lineage, mainly myelodysplastic neoplasms (MDS) and/or acute myeloid leukemia (AML).