SMC4 and glioblastoma: In both LGG (n = 532) and GBM (n = 169) datasets, NFIA and SMC4 exhibited a significant positive correlation (R = 0.34, P = 8.9e-16 for LGG; R = 0.35, P = 5.6e-06 for GBM; Supplementary Figure 7), suggesting that NFIA may transcriptionally regulate SMC4.