Immune agonists activate the host immune system and amplify tumor immunogenicity, thereby reprogramming immunosuppressive microenvironments and promoting T cell infiltration in cold tumors— thereby potentiating PD-1 inhibitor activity.Immune agonists activate the host immune system and amplify tumor immunogenicity, thereby potentiating PD-1 inhibitor activity (10). This evidence concerns the gene PDCD1 and neoplasm.