Ang- (1-7) (generated from Ang I and Ang II) could promote xenograft tumor growth in nude mice and migration of caki-1 and caki-2 cell lines in vitro (98), and combined administration of sunitinib and telmisartan (a renin-angiotensin-system antagonist) was observed to induce more necrosis and less neo-angiogenesis in 786-O cell line xenograft in mice, indicating the potential role and therapeutic value of renin-angiotensin-system in RCC (99). The gene discussed is REN; the disease is renal cell carcinoma.