IL-6 secreted by astrocytes in PD can induce neuronal death through conditioned media, an effect that can be inhibited by the IL-6R blocking antibody tocilizumab, indicating the crucial role of IL-6 in neuroinflammation and neurodegeneration in PD (Pons-Espinal et al., 2024). The gene discussed is IL6R; the disease is Parkinson disease.