In addition, pharmacological activation of CCKAR in the mPOA of mice exposed to 3-day SCS through daily infusion of the selective CCKAR agonist A71623 (75 ng in 300 nl per side) [34] induced anxiety-like behaviors, aggression and social recognition impairment (Fig. 4J–O), mirroring the outcomes observed with intra-mPOA CCKAR overexpression and chemogenetic activation of mPOAGad2 neurons. The gene discussed is CCKAR; the disease is Anxiety.