Under the protection of alginate that avoids phagocytosis, Chl. Continuously produced O2 through decomposition of water and energy conversion, alleviated tumor hypoxia, lowered vascular endothelial growth factor (VEGF) and hypoxia-inducing factor (HIF-1α), and thus inhibited growth and metastasis of tumor cells (Zhou et al.2019). The gene discussed is HIF1A; the disease is neoplasm.