XIAP and lung adenocarcinoma: For example, Chl. could induce a decrease in the viability of A549 (a non-small-cell lung cancer cell line) and CL1–5 (a lung adenocarcinoma cell line) via mitochondria-mediated apoptosis by down-regulating B cell lymphoma 2 (Bcl-2) (Bcl-2), X-linked inhibitor of apoptosis (XIAP), and surviving (Lin et al.2017).