IRF3 and neoplasm: Wherein, SP acted as an in situ oxygen factory for the alleviation of hypoxic TME, restoring stimulator of interferon gene/TANK-binding kinase 1/interferon regulatory factor 3 (STING/TBK1/IRF3) signaling and immune cells activation, while Fe3O4@mSiO2 NPs afforded SP with magnetic targeting ability to deliver ADU, which played a collaborative role in remodeling the immunosuppressive TME and provided a promising strategy for boosting anti-tumor immunity.