However, we did not observe loss of cilia or any gross morphological effects on primary cilia in the neurons with the ALS variant knock-ins, and previous reports have shown either complete loss of cilia with lowered CFAP410 levels or only partial loss of cilia upon complete knock-out, suggesting a mutation or cell-type dependent effect.10 The gene discussed is CFAP410; the disease is amyotrophic lateral sclerosis.