The selectivity of BIOT-NFL against GBM cells as well as its ability to form peptide-nanofibers, previously demonstrated in our prior work (Alnemeh-Al Ali et al., 2022; Griveau et al., 2022), motivated our investigation into a potential new nanosystem that combines BIOT-NFL with lipid nanocapsules loaded with Colchicine (Col-LNCs). The gene discussed is NEFL; the disease is glioblastoma.