APOB and hereditary disease: In this regard, targeted NGS panels are the routine diagnostic tool of well-characterized familial disorders, such as familial hypercholesterolemia with a panel that integrate key genes implicated in lipid regulation, including proprotein convertase subtilisin/kexin type 9 (PCSK9) along with low density lipoprotein receptor (LDLR) and apolipoprotein B (APOB) genes (13).