Intrahepatic cholestasis of pregnancy (ICP) is a common gestational complication characterized by pruritus, elevated total serum bile acids (TSBAs), and abnormal alanine aminotransferase (ALT) and aspartate transaminase (AST) levels, usually occurring in the second and third trimesters when the serum estrogen and progesterone levels are highest (Kenyon et al., 2002). The gene discussed is GPT; the disease is Pruritus.