In contrast, lymphocytes play a pivotal role in the host immune defense against tumors by inducing the apoptosis of tumor cells, inhibiting their growth and migration, and mediating cytotoxic effects.31 Additionally, platelets have been shown to promote tumor angiogenesis through secreting angiogenic factors, such as vascular endothelial growth factor and platelet-derived growth factor, providing essential nutrients for tumor growth and expansion.32,33. The gene discussed is VEGFA; the disease is neoplasm.