There was no statistically significant difference between patients with and without new sensitization in terms of age, gender, disease duration, presence of asthma, severity of asthma, presence of AD, duration of SCIT, initial sensitization status, initial serum median total IgE, median blood eosinophil and basophil count, SPT diameter values for DF and DP, eosinophil count change. The gene discussed is IGHE; the disease is asthma.