NFKB1 and type 2 diabetes mellitus: (67) showed that the alcohol metabolite acetaldehyde activates the NF-κB pathway and promotes the release of pro-inflammatory factors, such as IL-6 and TNF-α, which superimposes with the SARS-CoV-2-induced cytokine storm, thus exacerbating CVD risk in patients with T2DM in terms of inflammatory pathways.