Given that extensive RNA-seq analyses have consistently identified dysregulated fatty acid metabolism as a mitochondrial energy metabolic subtype associated with HF, and considering the undetermined roles of CSDC2 and SMCO4 in lipid metabolism within cardiomyocytes, we further explored their functional contributions to fatty acid metabolism in cardiomyocytes of HF patients. This evidence concerns the gene SMCO4 and hydrops fetalis.