Consistent with the original study, we found that CSF OCBs (OR 6.99, [CI: 2.00–24.45]) and DIT in any follow-up MRI (new T2-lesions: OR 4.50, [CI: 1.60–12.69], GAD+: OR 7.47, [CI: 2.33–24.05]) are independent risk factors of conversion to multiple sclerosis (P< 0.01) (Supplementary Table 1). This evidence concerns the gene GAD1 and multiple sclerosis.