LRP1 and early-onset autosomal dominant Alzheimer disease: Moreover, αβ peptides, such as αβ 40 and αβ 42, which are associated with Alzheimer’s disease, are eliminated from the brain by the action of the Lrp-1 protein.(42) This study found that fish oil supplementation increased the Lrp-1 gene expression in STZ-LPS-induced rats, demonstrating that the Lrp-1 protein was well generated.