Similar bone pathologies, including an increased occurrence of osteoporosis, osteoarthritis, arthropathy, joint replacements, and a consecutive decrease in BMD, were reported in HFE-hemochromatosis patients,6,26,27 who suffer from genetic iron overload due to the disruption of the iron sensing-hepcidin pathway.28–30. Here, HAMP is linked to hemochromatosis type 1.