Indeed, for instance, the increasing use of A-GLP1 has recently been linked to several side effects including not only gastrointestinal disorders, hypotension, syncope, arthritis disorders, nephrolithiasis, interstitial nephritis drug-induced pancreatitis (Xie et al., 2025), but also severe ophthalmological complications (Katz et al., 2025) compared to usual care. This evidence concerns the gene GLP1R and digestive system disorder.