YAP1 and Alzheimer disease: Accordingly, integrating prior literature with the findings of the present study, it is hypothesized that FGF2 and YAP1 may exert cognitive-improving effects through the mediation of ferroptosis, a pivotal pathogenic mechanism in AD, presumably via the attenuation of neuroinflammation, oxidative stress, and mitochondrial dysfunction, although this necessitates further in-depth exploration and validation (Wang F. et al., 2022).