Specifically, Chen et al. demonstrated that FGF2 protects endothelial cells via KLF2-mediated ferroptosis inhibition (Chen R. et al., 2023), while YAP1 reduces oxidative stress and inflammation, and promotes cell survival in diseases like acute lung injury (Zhang et al., 2022) and osteoarthritis (Chen F. et al., 2023; Chen R. et al., 2023). Here, KLF2 is linked to acute lung injury.