Moreover, PI3K/Akt activation was found to be elevated following infection with poxviruses, including vaccinia, cowpox (Soares et al., 2009), and rabbitpox (myxoma) viruses (Wang G. et al., 2006), contributing to apoptosis suppression (Soares et al., 2009), enhanced viral mRNA translation (Zaborowska and Walsh, 2009), and poxvirus morphogenesis (McNulty et al., 2010). Here, PIK3CD is linked to infection.