Researchers have created mouse models with mutations in specific AD-related genes (e.g., APP and PSEN1) that exhibit the key pathologies of AD, amyloid plaques and neuroprogenitor fibrillary tangles, which endow a critical means of delving deeper into the mechanisms of disease onset and diagnostic approaches (Yeapuri et al., 2025). This evidence concerns the gene PSEN1 and Alzheimer disease.