APOE and Alzheimer disease: In mice, this editing strategy not only cut down on amyloid accumulation and associated neuroinflammatory markers, but also markedly increased the level of sAPPα, which coincides with the beneficial results generated by the APOE4-Christchurch gene mutation mimicry study, and also exhibits the possibility of serving as a potential intervention for APOE4-related AD (Sun et al., 2019).The development of gene editing technology in AD treatment depends on breakthroughs in many aspects.